Research

The Translational Research Laboratory is interested in the pathobiology of platelets and platelet molecules.  We are currently focused on improved diagnosis and novel therapeutics for heparin induced thrombocytopenia/thrombosis (HITT).  We have recently published on  novel assays which may improve the precision and accuracy for diagnosis HITT.  Have also published on novel small molecules that interfere with the formation of heparin:PF4 complexes, which we call PF4 Antagonists (POF4As).  We are actively working to improve the potency and pharmacology of PF4As towards the development of PF4As as a therapeutic option for the treatment and/or prevention of HIT.  We are also interested in the pathgobiology of HIT as well as other platelet disorders.

Lab Personnel

• Connor McCloskey, BS, Laboratory Supervisor
• Olga Morzhanaeva, BS, Research Assistant I
• Jason Sperry, BS, Research Assistant I
• Pallashri Saha, PhD, Research Scientist 

Funding Support

• NIH R42 HL123126  NYBC PI: Sachais 09/2016 - 06/2023 "Small Molecule Antagonists of PF4 for the treatment and prevention of HIT"

• NIH R44HL145783    Tabadadze (PI); Sachais (NYBC PI)  03/2019-02/2023 " A closed system for pathogen reduction of red blood cells for transfusion”

• 75N92019D00037  Hod (PI); Sachais (NYBC PI)  04/2019-03/2026 Recipient Epidemiology and Donor Evaluation Study IV-P Domestic Hub (Federal Gov)

Education and Training