Xiuli An, MD, PhD

Title

Head, Laboratory of Membrane Biology
Associate Member, Lindsley F. Kimball Research Institute

Research Area

Our research focus is on developing a detailed molecular understanding of regulation of red cell production referred to as erythropoiesis. Erythropoiesis occurs exclusively in erythroid niches termed erythroblastic island (EBI) which is composed of a central macrophage surrounded by developing erythroid cells. Our lab has developed methods to purify both human and mouse erythroid cells at distinct developmental stages and methods to quantify the progress of erythroid differentiation in vivo.  We have also developed methods to purify the EBI macrophages Through RNA-seq analysis, the lab has constructed global transcriptomes of human and murine erythroid cells as well as EBI macrophages. We are currently working on three main research areas: 1) regulation of erythropoiesis with focus on mechanisms for erythroblast enucleation; 2) how EBI macrophages regulate erythropoiesis; 3) Improving ex vivo red cell production from stem cells.

Contact Information

Phone: +1 (212) 570-3247

Lab Personnel

  • Yaomei Wang, MD, PhD, Research Fellow
  • Xinhua Guo, MS, Senior Research Associate
  • Yongshuai Han, BS, Visiting Scientist, PhD Student
  • Huan Zhang, BS, Visiting Scientist, PhD Student
  • Shihui Wang, BS, Visiting Scientist PhD Student
  • Lingdi Zhao, MD, PhD, Visiting Scientist

Funding Support

  • Hugoton Foundation Grant An (PI) 1/1/2018 – 12/31/2018 “Regulation of Human Early Stage Erythropoiesis”

  • NIH R01 HL140625 An, Lobo, Westhoff (Multi-PI) 12/15/2017-11/30/2021 "Use of forward genetic approaches to identify Babesia receptors”

Education and Training

Doctoral Training
MD Henan Medical University, China
PhD in Biochemistry, Tokyo Women’s Medical University, Japan

Post-doctoral Training
Molecular Biology and Cell Biology, Lawrence Berkeley National Laboratory, CA

LIST OF PUBLICATIONS