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Dr. Vinchi, LFKRI’s head of the iron research program, was recently invited to give a plenary talk at the presidential symposium of the second biggest hematology congress, the European Hematology Association Meeting, that was held in Stockholm June 14-17, 2018.

Dr. Vinchi showed that several pathologic conditions are associated with excessive iron accumulation in macrophages and that these cells develop different functional phenotypes according to the iron source they are exposed to (free heme or iron vs red blood cells). Particularly, she highlighted how in mice, repeated red blood cell transfusions attenuate the inflammatory response of macrophages to infectious stimuli, thereby negatively impacting the innate immune response. These results provide an additional explanation for the increased risk of infections in chronically transfused patients. 

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